Article
Ex vivo hyperpolarized MR spectroscopy on isolated renal tubular cells: A novel technique for cell energy phenotyping.
Magnetic resonance in medicine - 1 Aug 2017
Juul Troels, Palm Fredrik, Nielsen Per Mose, Bertelsen Lotte Bonde, Laustsen Christoffer
Abstract excerpt
PURPOSE: It has been demonstrated that hyperpolarized 13 C MR is a useful tool to study cultured cells. However, cells in culture can alter phenotype, which raises concerns regarding the in vivo significance of such findings. Here we investigate if metabolic phenotyping using hyperpolarized 13 C MR is suitable for cells isolated from kidney tissue, without prior cell culture. METHODS: Isolation of tubular cells...
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