Article
Genetic risk factors for antiepileptic drug-induced hypersensitivity reactions in Israeli populations.
Epilepsia - 1 Oct 2016
Israel Shoshana, Maggio Nicola, Ekstein Dana, Zaid Huda, Firer Maria, Bederovsky Yana, Noyman Iris, Gandelman-Marton Revital, Blatt Ilan, Brautbar Chaim, Marom Eli, Nahlieli Dil Dorit, Berman Erez, Sabag David, Ingber Arieh, Eyal Sara
Abstract excerpt
The human leukocyte antigen (HLA) alleles B*15:02 and A*31:01 have been identified as predictive markers of adverse cutaneous effects of carbamazepine and phenytoin in Asian and North European populations, respectively. Our aim was to estimate the distribution of these alleles in Jewish and Arab populations in Israel. The HLA-B*15:02 and HLA-A*31:01 carrier rate was estimated based on data from the Hadassah Bone...
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