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Article

Exacerbated mechanical hyperalgesia in rats with genetically predisposed depressive behavior: role of melatonin and NMDA receptors.

Pain - 1 Dec 2012

Wang Shuxing, Tian Yinghong, Song Li, Lim Grewo, Tan Yonghui, You Zerong, Chen Lucy, Mao Jianren

Abstract excerpt

A connection between pain and depression has long been recognized in the clinical setting; however, its mechanism remains unclear. This study showed that mechanical hyperalgesia induced by unilateral temporomandibular joint (TMJ) inflammation was exacerbated in Wistar-Kyoto (WKY) rats with genetically predisposed depressive behavior. Reciprocally, TMJ inflammation enhanced depressive behavior such that a lower...

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Identifiers

PMID: 23046768
DOI: 10.1016/j.pain.2012.08.016
PMCID: PMC3494817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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