Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction.

doi:10.1038/nn.2941

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Article

Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction.

Nature neuroscience - 23 Oct 2011

Mogil Jeffrey S, Sorge Robert E, LaCroix-Fralish Michael L, Smith Shad B, Fortin Anny, Sotocinal Susana G, Ritchie Jennifer, Austin Jean-Sebastien, Schorscher-Petcu Ara, Melmed Kara, Czerminski Jan, Bittong Rosalie A, Mokris J Brad, Neubert John K, Campbell Claudia M, Edwards Robert R, Campbell James N, Crawley Jacqueline N, Lariviere William R, Wallace Margaret R, Sternberg Wendy F, Balaban Carey D, Belfer Inna, Fillingim Roger B

Abstract excerpt

Quantitative trait locus mapping of chemical/inflammatory pain in the mouse identified the Avpr1a gene, which encodes the vasopressin-1A receptor (V1AR), as being responsible for strain-dependent pain sensitivity to formalin and capsaicin. A genetic association study in humans revealed the influence of a single nucleotide polymorphism (rs10877969) in AVPR1A on capsaicin pain levels, but only in male subjects...

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Identifiers

PMID: 22019732
DOI: 10.1038/nn.2941
PMCID: PMC3225498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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