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Article

Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites.

American journal of human genetics - 1 Dec 2004

Uitterlinden Andre G, Arp Pascal P, Paeper Bryan W, Charmley Patrick, Proll Sean, Rivadeneira Fernando, Fang Yue, van Meurs Joyce B J, Britschgi Theresa B, Latham John A, Schatzman Randall C, Pols Huibert A P, Brunkow Mary E

Abstract excerpt

Osteoporosis has a strong genetic component, but the genes involved are poorly defined. We studied whether the sclerosteosis/van Buchem disease gene (SOST) is an osteoporosis-risk gene by examining its association with bone-mineral density (BMD). Mutations in SOST result in sclerosteosis, and alterations in the SOST gene expression may be causal in the closely related van Buchem disease. We used a set of eight...

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Identifiers

PMID: 15514891
DOI: 10.1086/426458
PMCID: PMC1182139

Genes

SOST
SRP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites.PMID 15514891Read ↗

Relationship of sclerostin and secreted frizzled protein polymorphisms with bone mineral density: an association study with replication in postmenopausal women.Semantic proximity Read ↗

Association study of polymorphisms in the SOST gene region and parameters of bone strength and body composition in both young and elderly men: data from the Odense Androgen Study.Semantic proximity Read ↗

Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal modelsSemantic proximity Read ↗

Associations of polymorphisms in the SOST gene and bone mineral density in postmenopausal Chinese Women.Semantic proximity Read ↗

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)Semantic proximity Read ↗

The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis.Semantic proximity Read ↗

Computational and functional characterization of four SNPs in the SOST locus associated with osteoporosis.Semantic proximity Read ↗

Eight genes are highly associated with BMD variation in postmenopausal Caucasian women.Semantic proximity Read ↗

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Methylation of bone SOST, its mRNA, and serum sclerostin levels correlate strongly with fracture risk in postmenopausal women.Semantic proximity Read ↗

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