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Article

Cilium transition zone proteome reveals compartmentalization and differential dynamics of ciliopathy complexes.

Proceedings of the National Academy of Sciences of the United States of America - 30 Aug 2016

Dean Samuel, Moreira-Leite Flavia, Varga Vladimir, Gull Keith

Abstract excerpt

The transition zone (TZ) of eukaryotic cilia and flagella is a structural intermediate between the basal body and the axoneme that regulates ciliary traffic. Mutations in genes encoding TZ proteins (TZPs) cause human inherited diseases (ciliopathies). Here, we use the trypanosome to identify TZ components and localize them to TZ subdomains, showing that the Bardet-Biedl syndrome complex (BBSome) is more distal in...

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Source

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Identifiers

PMID: 27519801
DOI: 10.1073/pnas.1604258113
PMCID: PMC5024643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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