Article

<i>Drosophila</i> sensory cilia lacking MKS-proteins exhibit striking defects during development but only subtle defects in adults

2016-06-09

Abstract excerpt

Cilia are conserved organelles that have important motility, sensory and signalling roles. The transition zone (TZ) at the base of the cilium is critical for cilia function, and defects in several TZ proteins are associated with human congenital ciliopathies such as Nephronophthisis (NPHP) and Meckel Gruber syndrome (MKS). In several species, MKS and NPHP proteins form separate complexes that cooperate with Cep290...

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Literature Corpus work: 14f729a0-d7e2-5904-9f49-6555f47bf2c0
DOI: 10.1101/058081

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