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Article

Mathematical modeling of lymphocytes selection in the germinal center.

Journal of mathematical biology - 1 Mar 2017

Milisic Vuk, Wainrib Gilles

Abstract excerpt

Lymphocyte selection is a fundamental process of adaptive immunity. In order to produce B-lymphocytes with a target antigenic profile, mutation selection and division occur in the germinal center, a specific part of lymph nodes. We introduce in this article a simplified mathematical model of this phenomenon, taking into account the main mechanisms. This model is written as a non-linear, non-local, inhomogeneous...

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PMID: 27515800
DOI: 10.1007/s00285-016-1038-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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