Article
The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine.
PloS one - 1 Jan 2016
McKinney Brett A, Lareau Caleb, Oberg Ann L, Kennedy Richard B, Ovsyannikova Inna G, Poland Gregory A
Abstract excerpt
Although many diseases and traits show large heritability, few genetic variants have been found to strongly separate phenotype groups by genotype. Complex regulatory networks of variants and expression of multiple genes lead to small individual-variant effects and difficulty replicating the effect of any single variant in an affected pathway. Interaction network modeling of GWAS identifies effects ignored by...
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