Article
Surfing a genetic association interaction network to identify modulators of antibody response to smallpox vaccine.
Genes and immunity - 1 Dec 2010
Davis N A, Crowe J E, Pajewski N M, McKinney B A
Abstract excerpt
The variation in antibody response to vaccination likely involves small contributions of numerous genetic variants, such as single-nucleotide polymorphisms (SNPs), which interact in gene networks and pathways. To accumulate the bits of genetic information relevant to the phenotype that are distributed throughout the interaction network, we develop a network eigenvector centrality algorithm (SNPrank) that is...
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