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Article

Evaluating the association between the SHANK3 gene and bipolar disorder.

Psychiatry research - 30 Oct 2016

Zhang Chen, Wu Zhiguo, Hong Wu, Peng Daihui, Fang Yiru

Abstract excerpt

BACKGROUND: Previous studies have shown that the genes involved in synaptic density and plasticity were downregulated in bipolar disorder (BD) postmortem brains. The SHANK3 (SH3 and multiple ankyrin repeat domain 3) protein is a scaffold protein enriched in the postsynaptic density of excitatory synapses, and recent findings were suggestive of a possible role of SHANK3 in the development of BD. In this study, we...

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Identifiers

PMID: 27512916
DOI: 10.1016/j.psychres.2016.07.058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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