Article
Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA.
Journal of medicinal chemistry - 30 Jul 1998
Chen H, Teng L, Li J N, Park R, Mold D E, Gnabre J, Hwu J R, Tseng W N, Huang R C
Abstract excerpt
We had previously reported that tetramethyl-O-NGDA (M4N), a synthetic derivative of the naturally occurring nordihydroguaiaretic acid (NDGA), is able to inhibit HIV Tat transactivation by blocking host Sp1 protein at the Sp1 cognate binding site on the HIV LTR promoter. The present studies were u...
Topics
- Acyclovir
- Animals
- Antiviral Agents
- Cell Line, Transformed
- Chlorocebus aethiops
- Drug Resistance, Microbial
- Electrophoresis, Polyacrylamide Gel
- Herpesvirus 1, Human
- Herpesvirus 2, Human
- Immediate-Early Proteins
- Masoprocol
- Mutation
- Plasmids