Article
Pancreatic ductal adenocarcinoma in BRCA2 mutation carriers.
Endocrine-related cancer - 1 Oct 2016
de Mestier Louis, Danset Jean-Baptiste, Neuzillet Cindy, Rebours Vinciane, Cros Jérôme, Soufir Nadem, Hammel Pascal
Abstract excerpt
Germline BRCA2 mutations are the first known cause of inherited (familial) pancreatic ductal adenocarcinoma (PDAC). This tumor is the third most frequent cancer in carriers of germline BRCA2 mutations, as it occurs in around 10% of BRCA2 families. PDAC is known as one of the most highly lethal cancers, mainly because of its chemoresistance and frequently late diagnosis. Based on recent developments in molecular...
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