A novel GATA4 loss-of-function mutation responsible for familial dilated cardiomyopathy.

Abstract excerpt

Dilated cardiomyopathy (DCM) is the most common form of primary myocardial disorder and is associated with substantial morbidity and mortality. Increasing evidence suggests that genetic risk factors play an important role in the pathogenesis of idiopathic DCM. However, DCM is a genetically heterogeneous disease, and the genetic defects responsible for DCM in an overwhelming majority of cases remain to be...

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• Aged
• Alternative Splicing
• Cardiomyopathy, Dilated
• GATA4 Transcription Factor
• Mutation, Missense