Article
Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions.
Cell reports - 8 Mar 2022
Bonthuis Paul J, Steinwand Susan, Stacher Hörndli Cornelia N, Emery Jared, Huang Wei-Chao, Kravitz Stephanie, Ferris Elliott, Gregg Christopher
Abstract excerpt
Noncanonical genomic imprinting can cause biased expression of one parental allele in a tissue; however, the functional relevance of such biases is unclear. To investigate ethological roles for noncanonical imprinting in dopa decarboxylase (Ddc) and tyrosine hydroxylase (Th), we use machine learning to decompose naturalistic foraging in maternal and paternal allele mutant heterozygous mice. We uncover distinct...
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