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Article

Assessing the Cognitive Translational Potential of a Mouse Model of the 22q11.2 Microdeletion Syndrome.

Cerebral cortex (New York, N.Y. : 1991) - 1 Oct 2016

Nilsson Simon Ro, Fejgin Kim, Gastambide Francois, Vogt Miriam A, Kent Brianne A, Nielsen Vibeke, Nielsen Jacob, Gass Peter, Robbins Trevor W, Saksida Lisa M, Stensbøl Tine B, Tricklebank Mark D, Didriksen Michael, Bussey Timothy J

Abstract excerpt

A chromosomal microdeletion at the 22q11.2 locus is associated with extensive cognitive impairments, schizophrenia and other psychopathology in humans. Previous reports indicate that mouse models of the 22q11.2 microdeletion syndrome (22q11.2DS) may model the genetic basis of cognitive deficits relevant for neuropsychiatric disorders such as schizophrenia. To assess the models usefulness for drug discovery, a...

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PMID: 27507786
DOI: 10.1093/cercor/bhw229
PMCID: PMC5028007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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