Article
MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro.
The international journal of neuropsychopharmacology - 1 Dec 2016
Wei Ya Bin, Melas Philippe A, Villaescusa J Carlos, Liu Jia Jia, Xu Ning, Christiansen Søren Hofman, Elbrønd-Bek Heidi, Woldbye David Paul Drucker, Wegener Gregers, Mathé Aleksander A, Lavebratt Catharina
Abstract excerpt
BACKGROUND: MicroRNAs (miRNAs) are small regulatory molecules that cause translational repression by base pairing with target mRNAs. Cumulative evidence suggests that changes in miRNA expression may in part underlie the pathophysiology and treatment of neuropsychiatric disorders, including major depressive disorder (MDD). METHODS: A miRNA expression assay that can simultaneously detect 423 rat miRNAs (miRBase...
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