Article
Pharmacokinetics of a Once-Daily Dose of Tacrolimus Early After Liver Transplantation: With Special Reference to CYP3A5 and ABCB1 Single Nucleotide Polymorphisms.
Annals of transplantation - 9 Aug 2016
Miyata Yoichi, Akamatsu Nobuhisa, Sugawara Yasuhiko, Kaneko Junichi, Yamamoto Takehito, Suzuki Hiroshi, Arita Junichi, Sakamoto Yoshihiro, Hasegawa Kiyoshi, Tamura Sumihito, Kokudo Norihiro
Abstract excerpt
BACKGROUND The aim of the present study was to investigate the pharmacokinetics of the once-daily tacrolimus formulation (QD form) in relation to polymorphisms of the donor cytochrome P450 family 3 sub-family A polypeptide 5 (CYP3A5) gene and recipient adenosine triphosphate-binding cassette sub-family B member 1 (ABCB1) gene. MATERIAL AND METHODS A total of 80 consecutive living-donor liver transplant (LDLT)...
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