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Article

Tacrolimus pharmacokinetics and pharmacogenetics: influence of adenosine triphosphate-binding cassette B1 (ABCB1) and cytochrome (CYP) 3A polymorphisms.

Fundamental & clinical pharmacology - 1 Aug 2007

Op den Buijsch Robert A M, Christiaans Maarten H L, Stolk Leo M L, de Vries Johan E, Cheung Chi Yuen, Undre Nas A, van Hooff Johannes P, van Dieijen-Visser Marja P, Bekers Otto

Abstract excerpt

Tacrolimus, an immunosuppressant used after organ transplantation, has a narrow therapeutic range and its pharmacokinetic variability complicates its daily dose assessment. P-glycoprotein (P-gp), encoded by the adenosine triphosphate-binding cassette B1 (ABCB1) and the cytochrome (CYP) 3A4 and 3A...

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Source

Identifiers

PMID: 17635182
DOI: 10.1111/j.1472-8206.2007.00504.x

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17635182-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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