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Article

Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin.

ACS chemical neuroscience - 19 Oct 2016

Toma Tatsuya, Logan Matthew M, Menard Frederic, Devlin A Sloan, Du Bois J

Abstract excerpt

A novel family of small molecule inhibitors of voltage-gated sodium channels (NaVs) based on the structure of batrachotoxin (BTX), a well-known channel agonist, is described. Protein mutagenesis and electrophysiology experiments reveal the binding site as the inner pore region of the channel, analogous to BTX, alkaloid toxins, and local anesthetics. Homology modeling of the eukaryotic channel based on recent...

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Identifiers

PMID: 27501251
DOI: 10.1021/acschemneuro.6b00212
PMCID: PMC5555364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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