Article
Specificity and function of activating Ly-49 receptors.
Immunological reviews - 1 Jun 2001
Kane K P, Silver E T, Hazes B
Abstract excerpt
Inhibitory Ly-49 receptors allow murine natural killer (NK) cells to kill cells with aberrant class I MHC expression while sparing normal cells. This is accomplished by their recognition of specific class I MHC products and prevention of NK-cell lysis of cells that present a normal repertoire of class I MHC ligands--"the missing self hypothesis". However, Ly-49 receptors that lack the cytoplasmic immunoreceptor...
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