Article
Antibody-Dependent Cellular Cytotoxicity Activity of Effector Cells from HIV-Infected Elite and Viral Controllers.
AIDS research and human retroviruses - 1 Jan 2000
Isitman Gamze, Lisovsky Irene, Tremblay-McLean Alexandra, Kovacs Colin, Harris Marianne, Routy Jean-Pierre, Bruneau Julie, Wainberg Mark A, Tremblay Cécile, Bernard Nicole F
Abstract excerpt
Carriage of alleles encoding certain inhibitory natural killer (NK) cell receptor/HLA ligand KIR3DL1/HLA-B combinations is associated with protection from HIV infection and slow time to AIDS, implicating NK cells in HIV control. NK cells also mediate antibody-dependent cellular cytotoxicity (ADCC). ADCC has been identified as a correlate of protection in secondary analyses of the modestly protective RV144 Thai...
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