Article
Comparative Analysis of Genome and Epigenome in Closely Related Medaka Species Identifies Conserved Sequence Preferences for DNA Hypomethylated Domains.
Zoological science - 1 Aug 2016
Uno Ayako, Nakamura Ryohei, Tsukahara Tatsuya, Qu Wei, Sugano Sumio, Suzuki Yutaka, Morishita Shinichi, Takeda Hiroyuki
Abstract excerpt
The genomes of vertebrates are globally methylated, but a small portion of genomic regions are known to be hypomethylated. Although hypomethylated domains (HMDs) have been implicated in transcriptional regulation in various ways, how a HMD is determined in a particular genomic region remains elusive. To search for DNA motifs essential for the formation of HMDs, we performed the genome-wide comparative analysis of...
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