Article
Conservation and divergence of methylation patterning in plants and animals.
Proceedings of the National Academy of Sciences of the United States of America - 11 May 2010
Feng Suhua, Cokus Shawn J, Zhang Xiaoyu, Chen Pao-Yang, Bostick Magnolia, Goll Mary G, Hetzel Jonathan, Jain Jayati, Strauss Steven H, Halpern Marnie E, Ukomadu Chinweike, Sadler Kirsten C, Pradhan Sriharsa, Pellegrini Matteo, Jacobsen Steven E
Abstract excerpt
Cytosine DNA methylation is a heritable epigenetic mark present in many eukaryotic organisms. Although DNA methylation likely has a conserved role in gene silencing, the levels and patterns of DNA methylation appear to vary drastically among different organisms. Here we used shotgun genomic bisulfite sequencing (BS-Seq) to compare DNA methylation in eight diverse plant and animal genomes. We found that patterns...
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