Effective bet-hedging through growth rate dependent stability.

doi:10.1073/pnas.2211091120

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Article

Effective bet-hedging through growth rate dependent stability.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2023

de Groot Daan H, Tjalma Age J, Bruggeman Frank J, van Nimwegen Erik

Abstract excerpt

Microbes in the wild face highly variable and unpredictable environments and are naturally selected for their average growth rate across environments. Apart from using sensory regulatory systems to adapt in a targeted manner to changing environments, microbes employ bet-hedging strategies where cells in an isogenic population switch stochastically between alternative phenotypes. Yet, bet-hedging suffers from a...

Topics

Biological Evolution
Phenotype
Acclimatization
Adaptation, Physiological

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PMID: 36780518
DOI: 10.1073/pnas.2211091120
PMCID: PMC9974493

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