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Article

Functional characteristics of a double positive feedback loop coupled with autorepression.

Physical biology - 19 Dec 2008

Banerjee Subhasis, Bose Indrani

Abstract excerpt

We study the functional characteristics of a two-gene motif consisting of a double positive feedback loop and an autoregulatory negative feedback loop. The motif appears in the gene regulatory network controlling the functional activity of pancreatic beta-cells. The model exhibits bistability and hysteresis in appropriate parameter regions. The two stable steady states correspond to low (OFF state) and high (ON...

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PMID: 19098361
DOI: 10.1088/1478-3975/5/4/046008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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