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Article

A case-control study of innate immunity pathway gene polymorphisms in Puerto Ricans reveals association of toll-like receptor 2 +596 variant with asthma.

BMC pulmonary medicine - 5 Aug 2016

Ortiz-Martínez Mario G, Frías-Belén Orquídea, Nazario-Jiménez Sylvette, López-Quintero María, Rodríguez-Cotto Rosa I, Jiménez-Vélez Braulio D

Abstract excerpt

BACKGROUND: For many years, African Dust Storms (ADE) has been thought to be associated with high prevalence of asthma in Puerto Rico (PR). Endotoxins (ENX) have been associated with ADE particulate matter (PM) and are known to promote pro-inflammatory responses in lung cells of susceptible individuals through the Toll-like receptor (TLR2/4) signaling pathways. Genetic variants are plausible contributors to such...

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Source

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Identifiers

PMID: 27495363
DOI: 10.1186/s12890-016-0272-7
PMCID: PMC4974724

Genes

TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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