Article
Toll-like receptors and CD14 genes polymorphisms and susceptibility to asthma in Tunisian children.
Tissue antigens - 1 May 2008
Lachheb J, Dhifallah I B, Chelbi H, Hamzaoui K, Hamzaoui A
Abstract excerpt
Many studies have shown the implication of CD14 and toll-like receptors (TLRs) 2, 4 and 9 in the pathogenesis of asthma or atopy. To evaluate the association of CD14 and TLRs gene polymorphisms with asthma or atopy, 210 asthmatic children, 224 controls and 80 families were enrolled in this study. Six single nucleotide polymorphisms TLR2 (+2408 G-->A), TLR4 (+1196 C-->T), TLR4 (+896 A-->G), TLR9 (-1237 T-->C),...
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