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Article

Genetic polymorphisms in the CD14 gene are associated with monocyte activation and carotid intima-media thickness in HIV-infected patients on antiretroviral therapy.

Medicine - 1 Aug 2016

Yong Yean K, Shankar Esaki M, Westhorpe Clare L V, Maisa Anna, Spelman Tim, Kamarulzaman Adeeba, Crowe Suzanne M, Lewin Sharon R

Abstract excerpt

HIV-infected individuals on antiretroviral therapy (ART) are at increased risk of cardiovascular disease (CVD). Given the relationship between innate immune activation and CVD, we investigated the association of single-nucleotide polymorphisms (SNPs) in TLR4 and CD14 and carotid intima-media thickness (cIMT), a surrogate measurement for CVD, in HIV-infected individuals on ART and HIV-uninfected controls as a...

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Share to Anti-Retroviral Agents
Share to Antigens, Differentiation, Myelomonocytic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carotid Intima-Media Thickness

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Share to CD163 Antigen

Share to Chemokine CCL2

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Source

Open in PubMed Open full text

Identifiers

PMID: 27495090
DOI: 10.1097/MD.0000000000004477
PMCID: PMC4979844

Genes

TLR4
CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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