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Whole genome sequencing reveals mycobacterial microevolution among concurrent isolates from sputum and blood in HIV infected TB patients.

BMC infectious diseases - 5 Aug 2016

Ssengooba Willy, de Jong Bouke C, Joloba Moses L, Cobelens Frank G, Meehan Conor J

Abstract excerpt

BACKGROUND: In the context of advanced immunosuppression, M. tuberculosis is known to cause detectable mycobacteremia. However, little is known about the intra-patient mycobacterial microevolution and the direction of seeding between the sputum and blood compartments. METHODS: From a diagnostic study of HIV-infected TB patients, 51 pairs of concurrent blood and sputum M. tuberculosis isolates from the same...

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AIDS-Related Opportunistic Infections
Bacterial Typing Techniques
Blood
Interspersed Repetitive Sequences
Minisatellite Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mycobacterium tuberculosis

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PMID: 27495002
DOI: 10.1186/s12879-016-1737-2
PMCID: PMC4974755

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