Article
The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.
Molecular psychiatry - 1 Feb 2021
Franzmeier Nicolai, Ren Jinyi, Damm Alexander, Monté-Rubio Gemma, Boada Mercè, Ruiz Agustín, Ramirez Alfredo, Jessen Frank, Düzel Emrah, Rodríguez Gómez Octavio, Benzinger Tammie, Goate Alison, Karch Celeste M, Fagan Anne M, McDade Eric, Buerger Katharina, Levin Johannes, Duering Marco, Dichgans Martin, Suárez-Calvet Marc, Haass Christian, Gordon Brian A, Lim Yen Ying, Masters Colin L, Janowitz Daniel, Catak Cihan, Wolfsgruber Steffen, Wagner Michael, Milz Esther, Moreno-Grau Sonia, Teipel Stefan, Grothe Michel J, Kilimann Ingo, Rossor Martin, Fox Nick, Laske Christoph, Chhatwal Jasmeer, Falkai Peter, Perneczky Robert, Lee Jae-Hong, Spottke Annika, Boecker Henning, Brosseron Frederic, Fliessbach Klaus, Heneka Michael T, Nestor Peter, Peters Oliver, Fuentes Manuel, Menne Felix, Priller Josef, Spruth Eike J, Franke Christiana, Schneider Anja, Westerteicher Christine, Speck Oliver, Wiltfang Jens, Bartels Claudia, Araque Caballero Miguel Ángel, Metzger Coraline, Bittner Daniel, Salloway Stephen, Danek Adrian, Hassenstab Jason, Yakushev Igor, Schofield Peter R, Morris John C, Bateman Randall J, Ewers Michael
Abstract excerpt
In Alzheimer's disease (AD), a single-nucleotide polymorphism in the gene encoding brain-derived neurotrophic factor (BDNFVal66Met) is associated with worse impact of primary AD pathology (beta-amyloid, Aβ) on neurodegeneration and cognitive decline, rendering BDNFVal66Met an important modulating factor of cognitive impairment in AD. However, the effect of BDNFVal66Met on functional networks that may underlie...
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