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Article

Phenotypic Assays for Characterizing Compound Effects on Induced Pluripotent Stem Cell-Derived Cardiac Spheroids.

Assay and drug development technologies - 1 Jan 2000

Sirenko Oksana, Hancock Michael K, Crittenden Carole, Hammer Matthew, Keating Sean, Carlson Coby B, Chandy Grischa

Abstract excerpt

Development of more complex, biologically relevant, and predictive cell-based assays for compound screening is a major challenge in drug discovery. The focus of this study was to establish high-throughput compatible three-dimensional (3D) cardiotoxicity assays using human induced pluripotent stem cell-derived cardiomyocytes. Using both high-content imaging and fast kinetic fluorescence imaging, the impact of...

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Identifiers

PMID: 28837356
DOI: 10.1089/adt.2017.792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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