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Article

Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1.

Human mutation - 1 Nov 2016

Capponi Simona, Geuens Thomas, Geroldi Alessandro, Origone Paola, Verdiani Simonetta, Cichero Elena, Adriaenssens Elias, De Winter Vicky, Bandettini di Poggio Monica, Barberis Marco, Chiò Adriano, Fossa Paola, Mandich Paola, Bellone Emilia, Timmerman Vincent

Abstract excerpt

Genetic discoveries in amyotrophic lateral sclerosis (ALS) have a significant impact on deciphering molecular mechanisms of motor neuron degeneration but, despite recent advances, the etiology of most sporadic cases remains elusive. Several cellular mechanisms contribute to the motor neuron degeneration in ALS, including RNA metabolism, cellular interactions between neurons and nonneuronal cells, and seeding of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27492805
DOI: 10.1002/humu.23062
PMCID: PMC5108433

Genes

HSPB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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