Article
Catechol-O-methyltransferase Val158Met polymorphism is associated with increased risk of multiple uterine leiomyomas either positive or negative for MED12 exon 2 mutations.
Journal of clinical pathology - 1 Mar 2017
Dzhemlikhanova Lyailya Kh, Efimova Olga A, Osinovskaya Natalia S, Parfenyev Sergey E, Niauri Dariko A, Sultanov Iskender Yu, Malysheva Olga V, Pendina Anna A, Shved Natalia Yu, Ivashchenko Tatyana E, Yarmolinskaya Maria I, Kakhiani Maka I, Gorovaya Ekaterina A, Tkachenko Antonina N, Baranov Vladislav S
Abstract excerpt
AIMS: To study the possible association of catechol-O-methyltransferase (COMT) Val158Met polymorphism with multiple and solitary uterine leiomyomas (ULs) and to check whether the COMT Val/Val genotype is associated with MED12 exon 2 mutations in fibroids. METHODS: The COMT Val158Met allele and genotype frequencies were compared between age-matched women with ULs (n=104) and controls (n=59). Patients with UL were...
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