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Article

Catechol-O-methyltransferase polymorphism is associated with increased uterine leiomyoma risk in different ethnic groups.

Journal of the Society for Gynecologic Investigation - 1 Feb 2006

Al-Hendy Ayman, Salama Salama A

Abstract excerpt

OBJECTIVES: Uterine leiomyomas (ULMs) are estrogen-dependent tumors that are more common in African American women. The etiology for such ethnic disparity is currently unknown. Catechol-O-methyltransferase (COMT) is an essential enzyme in estrogen metabolism. In the current study, we investigated the association of the functional COMT Val158Met polymorphism with ULM in different ethnic groups. We also studied the...

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Source

Identifiers

PMID: 16443508
DOI: 10.1016/j.jsgi.2005.10.007

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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