Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease.

doi:10.1053/j.gastro.2016.01.031

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease.

Gastroenterology - 1 May 2016

Li Qi, Lee Cheng Hiang, Peters Lauren A, Mastropaolo Lucas A, Thoeni Cornelia, Elkadri Abdul, Schwerd Tobias, Zhu Jun, Zhang Bin, Zhao Yongzhong, Hao Ke, Dinarzo Antonio, Hoffman Gabriel, Kidd Brian A, Murchie Ryan, Al Adham Ziad, Guo Conghui, Kotlarz Daniel, Cutz Ernest, Walters Thomas D, Shouval Dror S, Curran Mark, Dobrin Radu, Brodmerkel Carrie, Snapper Scott B, Klein Christoph, Brumell John H, Hu Mingjing, Nanan Ralph, Snanter-Nanan Brigitte, Wong Melanie, Le Deist Francoise, Haddad Elie, Roifman Chaim M, Deslandres Colette, Griffiths Anne M, Gaskin Kevin J, Uhlig Holm H, Schadt Eric E, Muise Aleixo M

Abstract excerpt

BACKGROUND & AIMS: Severe forms of inflammatory bowel disease (IBD) that develop in very young children can be caused by variants in a single gene. We performed whole-exome sequence (WES) analysis to identify genetic factors that might cause granulomatous colitis and severe perianal disease, with recurrent bacterial and viral infections, in an infant of consanguineous parents. METHODS: We performed targeted WES...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Consanguinity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crohn Disease

Share to England

Share to Minor Histocompatibility Antigens

Share to Nod2 Signaling Adaptor Protein

Share to Ontario

Share to Protein Interaction Maps

Share to Tripartite Motif Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26836588
DOI: 10.1053/j.gastro.2016.01.031
PMCID: PMC4842103

Genes

TRIM22
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease.PMID 26836588Read ↗

Genetic Sequencing of Pediatric Patients Identifies Mutations in Monogenic Inflammatory Bowel Disease Genes that Translate to Distinct Clinical Phenotypes.Semantic proximity Read ↗

Mutation spectrum of <i>NOD2</i> reveals recessive inheritance as a main driver of Early Onset Crohn’s DiseaseSemantic proximity Read ↗

Deleterious Genetic Variation Across the NOD Signaling Pathway Is Associated With Reduced NFKB Signaling Transcription and Upregulation of Alternative Inflammatory Transcripts in Pediatric Inflammatory Bowel Disease.Semantic proximity Read ↗

Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes.Semantic proximity Read ↗

Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn's Disease.Semantic proximity Read ↗

Diagnostic Yield of Next-generation Sequencing in Very Early-onset Inflammatory Bowel Diseases: A Multicentre StudySemantic proximity Read ↗

A Novel Rare Missense Variation of the <em>NOD2</em> Gene: Evidences of Implication in Crohn’s DiseaseSemantic proximity Read ↗

MYO5B and the Polygenic Landscape of Very Early-Onset Inflammatory Bowel Disease in an Ethnically Diverse Population.Semantic proximity Read ↗

Intestinal somatic mutations in inflammatory bowel disease patients are enriched in very early onset IBD and primary immunodeficiency genesSemantic proximity Read ↗

Novel NOD2 Mutation in Early-Onset Inflammatory Bowel Phenotype.Semantic proximity Read ↗

Molecular diagnosis of infantile onset inflammatory bowel disease by exome sequencing.Semantic proximity Read ↗

Exome sequencing analysis reveals variants in primary immunodeficiency genes in patients with very early onset inflammatory bowel disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.