Article
Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells.
Oncotarget - 30 Aug 2016
Arita Tomohiro, Ichikawa Daisuke, Konishi Hirotaka, Komatsu Shuhei, Shiozaki Atsushi, Ogino Shinpei, Fujita Yuji, Hiramoto Hidekazu, Hamada Junichi, Shoda Katsutoshi, Kosuga Toshiyuki, Fujiwara Hitoshi, Okamoto Kazuma, Otsuji Eigo
Abstract excerpt
BACKGROUND: Peritoneal metastasis consists of a highly complex series of steps, and the details of the underlying molecular mechanism remain largely unclear. In this study, the effects of tumor-derived exosomes (TEX) on the progression of gastric cancers were investigated in peritoneal metastasis. RESULTS: TEX were internalized in both mesothelial and gastric cancer cells in a cellular origin non-specific manner....
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