Article
MiRNA-3978 regulates peritoneal gastric cancer metastasis by targeting legumain.
Oncotarget - 13 Dec 2016
Zhang Yi, Wu Yuan-Yu, Jiang Jun-Nan, Liu Xue-Song, Ji Fu-Jian, Fang Xue-Dong
Abstract excerpt
Gastric cancer incidence and mortality are among the highest in China, with majority of the mortality related to peritoneal metastasis of gastric cancer. Treatment is limited to radical resection, which is impeded by incidence of metastasis at time of initial diagnosis, thus making it imperative to identify diagnostic and prognostic biomarkers. Legumain, a lysosomal cysteine endopeptidase of the asparaginyl...
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