Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Environmental risk and genetic susceptibility in Alzheimer's disease: Impacts on cognitive function and biomarkers.

Journal of Alzheimer's disease : JAD - 1 Jul 2026

Kanani Khushi, Ramakrishnan Prevena, Neupane Snabu, Misra Manali, Balmer-Brown Kaitlynn, Halteman Sarah, Warrick Tia

Abstract excerpt

BackgroundAlzheimer's disease (AD) involves interactions among genetic, environmental, and lifestyle factors, yet the contribution of environmental exposures to cognitive decline and biomarker changes remains unclear. Detoxification genes such as EPHX1 may influence susceptibility to environmental neurotoxicants.ObjectiveTo evaluate associations between environmental risk, cognitive outcomes, and AD biomarkers,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition

Share to Environmental Exposure

Share to Magnetic Resonance Imaging

Share to Neuropsychological Tests

Share to Positron-Emission Tomography

Share to tau Proteins

Source

Identifiers

PMID: 42179068
DOI: 10.1177/13872877261451855

Genes

EPHX1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Environmental risk and genetic susceptibility in Alzheimer's disease: Impacts on cognitive function and biomarkers.PMID 42179068Read ↗

Epidemiology and etiology of Alzheimer's disease: from genetic to non-genetic factors.Semantic proximity Read ↗

Epigenetics as a link between environmental factors and dementia riskSemantic proximity Read ↗

Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders.Semantic proximity Read ↗

Emerging risk of environmental factors: insight mechanisms of Alzheimer’s diseasesSemantic proximity Read ↗

Environmental factors in the development and progression of late-onset Alzheimer’s diseaseSemantic proximity Read ↗

The disease intersection of susceptibility and exposure: chemical exposures and neurodegenerative disease risk.Semantic proximity Read ↗

APOE ε4 allele modifies the association of lead exposure with age-related cognitive decline in older individuals.Semantic proximity Read ↗

Associations between air pollution and markers of neuroinflammation, synaptic dysfunction and core Alzheimer's disease pathology vary by APOE genotype.Semantic proximity Read ↗

A Systems Neuroscience Approach Identifies IL1B-CASP3 Signaling as a Molecular Link Between Polystyrene Exposure and Alzheimer's DiseaseSemantic proximity Read ↗

Genetic variability in pathways associates with pesticide-induced nervous system disease in the United StatesSemantic proximity Read ↗

Heavy metals toxicity on epigenetic modifications in the pathogenesis of Alzheimer's disease (AD)Semantic proximity Read ↗

LIFETIME JEM-DERIVED OCCUPATIONAL EXPOSURE BURDEN AND ODDS OF PARKINSON’S DISEASE AND PARKINSONISM IN A MATCHED CASE-CONTROL STUDYSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.