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APOE ε4 allele modifies the associations of toxic metals and their mixture with cognitive impairment among older adults.

Environmental research - 15 Aug 2024

Liu Qiang, Li Junzhe, Cheng Xuqiu, Chen Guimei, Zhang Yan, Tian Ziwei, Wang Yuan, Wang Hongli, Guo Xianwei, Li Huaibiao, Sun Liang, Hu Bing, Zhang Dongmei, Liang Chunmei, Sheng Jie, Tao Fangbiao, Wang Jun, Yang Linsheng

Abstract excerpt

BACKGROUND: The evidence of interactive effect of the toxic metal (TM) mixture and apolipoprotein E (APOE) ε4 gene on cognitive impairment in older adults is scarce. We aimed to explore whether the associations of single TMs and their mixture with cognitive impairment depend on APOE ε4 in Chinese community-dwelling older people. METHODS: A total of 1148 older adults from a subset of the baseline survey of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38754607
DOI: 10.1016/j.envres.2024.119148

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