Article
Loss of l(3)mbt leads to acquisition of the ping-pong cycle in Drosophila ovarian somatic cells.
Genes & development - 15 Jul 2016
Sumiyoshi Tetsutaro, Sato Kaoru, Yamamoto Hitomi, Iwasaki Yuka W, Siomi Haruhiko, Siomi Mikiko C
Abstract excerpt
In Drosophila germ cells, PIWI-interacting RNAs (piRNAs) are amplified through a PIWI slicer-dependent feed-forward loop termed the ping-pong cycle, yielding secondary piRNAs. However, the detailed mechanism remains poorly understood, largely because an ex vivo model system amenable to biochemical analyses has not been available. Here, we show that CRISPR-mediated loss of function of lethal (3) malignant brain...
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