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Article

Small-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains.

Journal of structural biology - 1 Dec 2016

Gakhar Lokesh, Bassuk Alexander G, Velez Gabriel, Khan Saif, Yang Jing, Tsang Stephen H, Mahajan Vinit B

Abstract excerpt

Calpain-5 is a calcium-activated protease expressed in the retina. Mutations in calpain-5 cause autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV, OMIM#193235). The structure of calpain-5 has not been determined, thus hindering the investigation of its proteolytic targets and pathological role in ADNIV. Herein, we report models of the proteolytic core of calpain-5 (mini-calpain-5) containing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27474374
DOI: 10.1016/j.jsb.2016.07.017
PMCID: PMC5118095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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