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Article

Impaired activity and membrane association of most calpain-5 mutants causal for neovascular inflammatory vitreoretinopathy.

Biochimica et biophysica acta. Molecular basis of disease - 1 Aug 2023

Geddes James W, Bondada Vimala, Croall Dorothy E, Rodgers David W, Gal Jozsef

Abstract excerpt

Neovascular inflammatory vitreoretinopathy (NIV) is a rare eye disease that ultimately leads to complete blindness and is caused by mutations in the gene encoding calpain-5 (CAPN5), with six pathogenic mutations identified. In transfected SH-SY5Y cells, five of the mutations resulted in decreased membrane association, diminished S-acylation, and reduced calcium-induced autoproteolysis of CAPN5. CAPN5 proteolysis...

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PMID: 37207905
DOI: 10.1016/j.bbadis.2023.166747
PMCID: PMC10332796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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