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Article

PD-L1 expression is associated with epithelial-to-mesenchymal transition in adenocarcinoma of the lung.

Human pathology - 1 Dec 2016

Kim Sehui, Koh Jaemoon, Kim Moon-Young, Kwon Dohee, Go Heounjeong, Kim Young A, Jeon Yoon Kyung, Chung Doo Hyun

Abstract excerpt

PD-1/PD-L1-targeted immunotherapy has emerged as a promising therapeutic strategy for pulmonary adenocarcinoma (pADC). Epithelial-to-mesenchymal transition (EMT) is involved in the progression and immune evasion of cancers. Therefore, we investigated the association between PD-L1 expression and EMT phenotype in pADC. Immunohistochemistry for E-cadherin (epithelial marker), ZEB1, SNAIL, SLUG, vimentin (mesenchymal...

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Source

Identifiers

PMID: 27473266
DOI: 10.1016/j.humpath.2016.07.007

Genes

EGFR
ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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