Virus‐cell and cell‐cell fusion mediated by the HIV‐1 envelope glycoprotein is inhibited by short gp41 N‐terminal membrane‐anchored peptides lacking the critical pocket domain

Abstract excerpt

ABSTRACT The interactions between the N‐ and C‐terminal heptad repeat (NHR and CHR) regions of the human immunodeficiency virus (HIV‐1) glycoprotein gp41 create a structure comprising a 6‐helix bundle (SHB). A sequence in the SHB named the “pocket” is crucial for the SHB's stability and for the fusion inhibitory activity of 36‐residue NHR peptide N36. We report that a short 27‐residue peptide, N27, which lacks...

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