Article
Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2016
Toda-Ishii Midori, Akaike Keisuke, Suehara Yoshiyuki, Mukaihara Kenta, Kubota Daisuke, Kohsaka Shinji, Okubo Taketo, Mitani Keiko, Mogushi Kaoru, Takagi Tatsuya, Kaneko Kazuo, Yao Takashi, Saito Tsuyoshi
Abstract excerpt
Recently, several studies have reported that dysfunctions in protein phosphatase 2A (PP2A) caused by alterations in protein phosphatase 2 regulatory subunit A, alpha (PPP2R1A) are responsible for tumorigenesis and tumor progression in several types of cancers. The impact of PPP2R1A mutations remains unknown in gastrointestinal stromal tumors (GISTs), although mutations in KIT and PDGFRA, which result in...
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