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Article

Alpha-1-antitrypsin deficiency in aneurysmal disease.

Human heredity - 1 Jan 2000

St Jean P, Hart B, Webster M, Steed D, Adamson J, Powell J, Ferrell R

Abstract excerpt

alpha 1-Antitrypsin (alpha 1-AT) deficiency may play a role in arterial aneurysmal disease by allowing increased proteolysis of arterial structural proteins. Alpha 1-AT levels are influenced by variation at the PI (protease inhibitor) locus. PI phenotypes were determined in 173 patients with abdominal aortic aneurysms (77 from Pittsburgh, 96 from London) and in 72 patients with intracranial aneurysms (26 from...

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Identifiers

PMID: 8666418
DOI: 10.1159/000154333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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