Alpha-1-antitrypsin deficiency in aneurysmal disease.

doi:10.1159/000154333

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Article

Alpha-1-antitrypsin deficiency in aneurysmal disease.

Human heredity - 1 Jan 2000

St Jean P, Hart B, Webster M, Steed D, Adamson J, Powell J, Ferrell R

Abstract excerpt

alpha 1-Antitrypsin (alpha 1-AT) deficiency may play a role in arterial aneurysmal disease by allowing increased proteolysis of arterial structural proteins. Alpha 1-AT levels are influenced by variation at the PI (protease inhibitor) locus. PI phenotypes were determined in 173 patients with abdo...

Topics

Aged
Alleles
Aortic Aneurysm, Abdominal
Female
Gene Frequency
Humans
Intracranial Aneurysm
Male
Middle Aged
Phenotype
Protease Inhibitors
Smoking
alpha 1-Antitrypsin
alpha 1-Antitrypsin Deficiency

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