A Scalable Permutation Approach Reveals Replication and Preservation Patterns of Network Modules in Large Datasets.

Abstract excerpt

Network modules-topologically distinct groups of edges and nodes-that are preserved across datasets can reveal common features of organisms, tissues, cell types, and molecules. Many statistics to identify such modules have been developed, but testing their significance requires heuristics. Here, we demonstrate that current methods for assessing module preservation are systematically biased and produce skewed p...

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