A quantum leap in the reproducibility, precision, and sensitivity of gene expression profile analysis even when sample size is extremely small.

Abstract excerpt

Transcript-level quantification is often measured across two groups of patients to aid the discovery of biomarkers and detection of biological mechanisms involving these biomarkers. Statistical tests lack power and false discovery rate is high when sample size is small. Yet, many experiments have very few samples (≤ 5). This creates the impetus for a method to discover biomarkers and mechanisms under very small...

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