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Article

Adenosine monophosphate deaminase 3 activation shortens erythrocyte half-life and provides malaria resistance in mice.

Blood - 1 Sept 2016

Hortle Elinor, Nijagal Brunda, Bauer Denis C, Jensen Lora M, Ahn Seong Beom, Cockburn Ian A, Lampkin Shelley, Tull Dedreia, McConville Malcolm J, McMorran Brendan J, Foote Simon J, Burgio Gaetan

Abstract excerpt

The factors that determine red blood cell (RBC) lifespan and the rate of RBC aging have not been fully elucidated. In several genetic conditions, including sickle cell disease, thalassemia, and G6PD deficiency, erythrocyte lifespan is significantly shortened. Many of these diseases are also associated with protection from severe malaria, suggesting a role for accelerated RBC senescence and clearance in malaria...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27465915
DOI: 10.1182/blood-2015-09-666834
PMCID: PMC5009516

Genes

AMPD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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